LMU Center for Neuropathology
+49 (89) 2180-78010
Fax: +49 (89) 2180-78037
The Herms' lab focuses on cellular neurobiology, clinical neuroscience, functional imaging, and developmental neurobiology. Research topics of the lab include the analysis of the physiological function of proteins that are critically involved in neurodegenerative disease like Alzheimer's or Parkinson's disease (AD,PD). Moreover we use transgenic mouse models of these diseases crossed with mice that express fluorescent proteins in various cell types for long-term in vivo two-photon imaging in order to understand the cascade of events that lead to synapse and neurons loss.
Potential projects in this lab would focus on:
1. the mechanisms of dendritic spine loss in AD, or
2. semi-quantitative immohistochemical studies on the expression of dendritic proteins in human AD-tissue performing double labeling approaches.
Applicants with experience in confocal microscopy would be preferred.
For background reading, please refer to: Fuhrmann et al. Nat. Neurosci. 2010, Kienast Nat. Med. 2010, Bittner et al. PLOSone 2010, Burgold et al. Acta Neuropath. 2011, Hokkanen et al. Hum. Mol. Gen. 2011.
Primary Technique(s): confocal microscopy, long-term in vivo two-photon imaging, neuronal calcium homeostasis, high-throughput drug screens
Model Organism(s): mice (and humans)