Biomedical Center of the LMU - Dept. Cell Biology (Anatomie III)
Helmholtz Center Munich, Institute of Structural Biology
Group Intracellular Transport & RNA Biology
Dept. Cell Biology (Anatomie III)
+49 (89) 2180-71633
Fax: +49 (0)89 / 2180-75882
Motor Protein-Dependent Transport of Cellular Cargo
Imagine a big city without a car driving and no mail being delivered. The resulting chaos is similar to what happens to a cell when its molecular transport systems are impaired.
Every eukaryotic cell contains motor protein complexe that transport a variety of different cargoes, like mRNAs, vesicles and organelles through the cytoplasm. Such active transport is also important during processes like asymmetric cell devision and neuronal plasticity.
A major goal in Dr. Niessing's group is the structural and functional characterization of transport complexes from yeast, fly and human. We wish to understand their (i) assembly, (ii) regulation and (iii) disassembly at the site of destination.
Primary Technique(s): X-ray crystallography, biophysical and biochemical approaches
Model Organism(s): Saccharomyces cerevisiae and higher eukaryotes